2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate

Base Information

Chemical Name:2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate
CAS No.:1350375-22-2
Molecular Formula:C₂HF₃O₂*C₂₆H₃₉N₃O
Molecular Weight:523.639
Hs Code.:

Synonyms:2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate

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Chemical Property of 2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate

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Technology Process of 2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate

There total 8 articles about 2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350375-51-7
1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

: 76-05-1
trifluoroacetic acid

: 1350375-22-2
2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate

Guidance literature:: 1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester; potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 4630-82-4
methyl cyclohexylcarboxylate

: 1350375-22-2
2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -70 °C

1.2: 1.5 h / -70 - 20 °C

2.1: osmium(VIII) oxide; sodium periodate; water / isopropyl alcohol / 24 h

3.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C

3.2: pH 10

4.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C

With sodium periodate; osmium(VIII) oxide; n-butyllithium; water; sodium tris(acetoxy)borohydride; diisopropylamine; potassium tert-butylate; acetic acid; In tetrahydrofuran; hexanes; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1350375-22-2
2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenyl}-2-aza-spiro[4.5]decan-1-one trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane; N,N-dimethyl-formamide / 72 h / 0 - 20 °C

2.1: potassium carbonate / acetonitrile / 40 h / 80 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 h / 0 - 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 8 h / 90 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h

6.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C

6.2: pH 10

7.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; dmap; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; palladium 10% on activated carbon; potassium tert-butylate; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;