4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester
CAS No.:1161413-03-1
Molecular Formula:C₁₉H₂₀F₂N₂O₂
Molecular Weight:346.377
Hs Code.:

Synonyms:4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester

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Chemical Property of 4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester

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Technology Process of 4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester

There total 1 articles about 4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 3863-11-4
3,4-difluoroaniline

: 1161413-03-1
4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: benzyl 4-oxo-1-piperidinecarboxylate; 3,4-difluoroaniline; With sodium tris(acetoxy)borohydride; sodium sulfate; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydrogencarbonate; In 1,2-dichloro-ethane;

Reference yield: 39.0%

: 1161413-03-1
4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester

: 79-03-8
propionyl chloride

: 1161413-10-0
4-[(3,4-difluoro-phenyl)-propionyl-amino]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1161413-03-1
4-(3,4-difluoro-phenylamino)-piperidine-1-carboxylic acid benzyl ester

: 202859-52-7
N-(3,4-difluorophenyl)-N-(piperidin-4-yl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: hydrogen / palladium on activated charcoal / tetrahydrofuran / 4 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;