(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Base Information

Chemical Name:(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide
CAS No.:1075230-13-5
Molecular Formula:C₁₈H₁₆FN₅OS
Molecular Weight:369.422
Hs Code.:

Synonyms:(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

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Chemical Property of (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

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Technology Process of (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

There total 10 articles about (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1075230-69-1
(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

: 53234-55-2
5-cyano-pyridine-2-carboxylic acid

: 1075230-13-5
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.9b00309

Reference yield:

: 1336669-71-6
(S)-3-amino-3-(2-fluoro-5-nitrophenyl)butan-1-ol

: 1075230-13-5
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 1.5 h / 20 °C

2: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 4 h / 0 °C

3: hydrazine hydrate / ethanol / 5 h / 20 °C

4: sulfuric acid; nitric acid / trifluoroacetic acid / 0.42 h / -20 °C

5: ammonium chloride; iron / toluene; water / 2 h / 80 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrogenchloride / methanol; water / 1 h / 0 °C

With hydrogenchloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sulfuric acid; nitric acid; iron; ammonium chloride; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; dichloromethane; water; toluene; trifluoroacetic acid;
DOI:10.1002/cmdc.201900478

Reference yield:

: (S)-N-((2-(2-fluorophenyl)-4-hydroxybutan-2-yl)carbamothioyl)benzamide

: 1075230-13-5
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 4 h / 0 °C

2: hydrazine hydrate / ethanol / 5 h / 20 °C

3: sulfuric acid; nitric acid / trifluoroacetic acid / 0.42 h / -20 °C

4: ammonium chloride; iron / toluene; water / 2 h / 80 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrogenchloride / methanol; water / 1 h / 0 °C

With hydrogenchloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sulfuric acid; nitric acid; iron; ammonium chloride; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; dichloromethane; water; toluene; trifluoroacetic acid;
DOI:10.1002/cmdc.201900478