(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

Base Information

Chemical Name:(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide
CAS No.:556801-43-5
Molecular Formula:C₂₈H₂₅FN₄O₄
Molecular Weight:500.529
Hs Code.:

Synonyms:(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

Suppliers and Price of (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

There total 7 articles about (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.18%

: 1074-82-4
potassium phtalimide

: 556801-42-4
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

: 556801-43-5
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

Guidance literature:: (R)-[N-3-(3'-fluoro-4'-(4"-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate; In N,N-dimethyl-formamide; at 80 ℃; Autoclave;

potassium phtalimide; With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 4h;

Reference yield:

: 92-54-6
4-phenyl-1-piperazine

: 556801-43-5
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 105 h / 20 °C

2.1: water; acetic acid; iron / ethanol

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4.1: n-butyllithium / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

5.1: triethylamine / dichloromethane / 1.08 h / 0 °C

6.1: potassium carbonate / 3 h

With n-butyllithium; water; iron; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 478079-57-1
3-fluoro-4-(4-phenylpiperazin-1-yl)aniline

: 556801-43-5
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: triethylamine / dichloromethane / 1.08 h / 0 °C

4.1: potassium carbonate / 3 h

With n-butyllithium; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;