methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Chemical Name:methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate
CAS No.:1374344-58-7
Molecular Formula:C₁₉H₁₆F₂N₈O₂
Molecular Weight:426.385
Hs Code.:

Synonyms:methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Chemical Property of methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Technology Process of methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

There total 8 articles about methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1374344-83-8
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

: 79-22-1
methyl chloroformate

: 1374344-58-7
methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1048340-35-7
3,5-difluoropyridine-2-carbonyl chloride

: 1374344-58-7
methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sodium chloride; water / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

3.1: hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

4.2: 1 h / 80 °C

5.1: palladium 10% on activated carbon; hydrogen; pyridine

6.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; sodium hydride; hydrazine hydrate; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1361570-31-1
methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

: 1374344-58-7
methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium chloride; water / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

2.1: hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3.2: 1 h / 80 °C

4.1: palladium 10% on activated carbon; hydrogen; pyridine

5.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; sodium hydride; hydrazine hydrate; sodium chloride; In pyridine; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;