methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate

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Chemical Name:methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate
CAS No.:1374344-64-5
Molecular Formula:C₂₀H₁₈F₂N₈O₂
Molecular Weight:440.412
Hs Code.:

Synonyms:methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate

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Chemical Property of methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate

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Technology Process of methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate

There total 8 articles about methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1374344-58-7
methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

: 74-88-4
methyl iodide

: 1374344-64-5
methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate

Guidance literature:: methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

Reference yield:

: 1374344-81-6
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

: 1374344-64-5
methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen; pyridine

2.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

3.2: -20 - 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1048340-35-7
3,5-difluoropyridine-2-carbonyl chloride

: 1374344-64-5
methyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}methylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sodium chloride; water / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

3.1: hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

4.2: 1 h / 80 °C

5.1: palladium 10% on activated carbon; hydrogen; pyridine

6.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

7.2: -20 - 20 °C / Inert atmosphere

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; sodium hexamethyldisilazane; sodium hydride; hydrazine hydrate; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;