(1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid
CAS No.:457612-42-9
Molecular Formula:C₂₀H₂₃O₅P
Molecular Weight:374.373
Hs Code.:

Synonyms:(1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid

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Chemical Property of (1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid

Chemical Property:

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Technology Process of (1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid

There total 1 articles about (1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 457612-41-8
{(1S,2S,3S,4S)-3,4-dimethoxy-2-[2-phenylethenyl]cyclopentyl}diphenylphosphine oxide

: 457612-42-9
(1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid

Guidance literature:: {(1S,2S,3S,4S)-3,4-dimethoxy-2-[2-phenylethenyl]cyclopentyl}diphenylphosphine oxide; With ozone; In methanol; at -78 ℃; for 2h;

With dihydrogen peroxide; at 40 - 70 ℃; for 2h;

With potassium permanganate; In water; acetone; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/jo025725v

Reference yield: 95.0%

: 67-56-1
methanol

: 457612-42-9
(1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid

: 457612-43-0
methyl (1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylate

Guidance literature:: With sulfuric acid; for 12h; Heating;
DOI:10.1021/jo025725v

Reference yield:

: 457612-42-9
(1R,2S,3S,5S)-5-(diphenylphosphonoyl)-2,3-dimethoxycyclopentanecarboxylic acid

: (1R,2S,3S,5S)-5-(diphenylphosphino)-2,3-dimethoxycyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / concentrated H₂SO₄ / 12 h / Heating

2: 93 percent / trichlorosilane; triethylamine / benzene / 24 h / 0 - 110 °C

3: 98 percent / sodium hydroxide / tetrahydrofuran; H₂O / 12 h / 50 °C

With sodium hydroxide; sulfuric acid; trichlorosilane; triethylamine; In tetrahydrofuran; water; benzene;
DOI:10.1021/jo025725v