4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester
CAS No.:1441755-76-5
Molecular Formula:C₃₁H₃₀Cl₂N₄O₄
Molecular Weight:593.51
Hs Code.:

Synonyms:4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

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Chemical Property of 4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

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Technology Process of 4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

There total 10 articles about 4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78025-22-6
(2-amino-4-chloro-phenoxy)-acetonitrile

: 1441755-84-5
4-[(4-chloro-phenyl)-hydroxy-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-76-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: 4-[(4-chloro-phenyl)-hydroxy-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester; With triethylamine; Methanesulfonic anhydride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

(2-amino-4-chloro-phenoxy)-acetonitrile; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1441739-72-5
4-formyl-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-76-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

2.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

With triethylamine; Methanesulfonic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 1441739-56-5
4-bromo-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-76-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

3.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

4.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; tert-butyl alcohol; 1.1: |Suzuki Coupling;