C₂₉H₃₅F₂N₆O₁₀PS

Base Information

• Chemical Name: C₂₉H₃₅F₂N₆O₁₀PS
• CAS No.: 948043-30-9
• Molecular Formula: C₂₉H₃₅F₂N₆O₁₀PS
• Molecular Weight: 728.668
• Mol file: 948043-30-9.mol

Synonyms:C₂₉H₃₅F₂N₆O₁₀PS

Chemical Property of C₂₉H₃₅F₂N₆O₁₀PS

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₂₉H₃₅F₂N₆O₁₀PS

There total 4 articles about C₂₉H₃₅F₂N₆O₁₀PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

C21H23IN6O7S (948043-26-3) + diethyl 1,1-difluoro-3-propynephosphonate (126181-58-6) → C29H35F2N6O10PS (948043-30-9)

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 60 ℃; for 1h;

DOI:10.1016/j.bmcl.2007.05.054

Reference yield:

diethyl 1,1-difluoro-4-(trimethylsilyl)but-3-ynylphosphonate (142685-06-1) → C29H35F2N6O10PS (948043-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / tetrabutylammonium fluoride; AcOH / tetrahydrofuran

2: 59 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / acetonitrile / 1 h / 60 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetonitrile; 2: Sonogashira reaction;

DOI:10.1016/j.bmcl.2007.05.054

Reference yield:

[(diethoxyphosphoryl)difluoromethyl]zinc bromide (82845-20-3) → C29H35F2N6O10PS (948043-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / CuBr / dimethylformamide / 20 °C

2: 97 percent / tetrabutylammonium fluoride; AcOH / tetrahydrofuran

3: 59 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / acetonitrile / 1 h / 60 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 3: Sonogashira reaction;

DOI:10.1016/j.bmcl.2007.05.054

upstream raw materials:

C₂₁H₂₃IN₆O₇S

diethyl 1,1-difluoro-3-propynephosphonate

diethyl 1,1-difluoro-4-(trimethylsilyl)but-3-ynylphosphonate

[(diethoxyphosphoryl)difluoromethyl]zinc bromide