(2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

Base Information

Chemical Name:(2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol
CAS No.:1246248-66-7
Molecular Formula:C₁₆H₂₆BrFO₃Si
Molecular Weight:393.369
Hs Code.:

Synonyms:(2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

Chemical Property:

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Technology Process of (2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

There total 4 articles about (2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1246248-65-6
{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

: 1246248-66-7
(2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

Guidance literature:: With AD mix-β; In water; tert-butyl alcohol; for 16h; Cooling with ice;

Reference yield:

: 1007-15-4
4-fluoro-3-bromoacetophenone

: 1246248-66-7
(2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene; tetrahydrofuran / 1 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 4 h / Cooling with ice; Reflux

2.1: boron trifluoride diethyl etherate / dichloromethane / 18 h / -5 °C / Molecular sieve

3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C / Inert atmosphere; Cooling with ice

4.1: AD mix-β / water; tert-butyl alcohol / 16 h / Cooling with ice

With 1H-imidazole; AD mix-β; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol;

Reference yield:

: 1194045-07-2
2-bromo-1-fluoro-4-(prop-1-en-2-yl)benzene

: 1246248-66-7
(2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / dichloromethane / 18 h / -5 °C / Molecular sieve

2: 1H-imidazole / dichloromethane / 20 h / 20 °C / Inert atmosphere; Cooling with ice

3: AD mix-β / water; tert-butyl alcohol / 16 h / Cooling with ice

With 1H-imidazole; AD mix-β; boron trifluoride diethyl etherate; In dichloromethane; water; tert-butyl alcohol;