[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Base Information

Chemical Name:[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate
CAS No.:1247008-47-4
Molecular Formula:C₃₀H₃₆N₂O₅
Molecular Weight:504.626
Hs Code.:

Synonyms:[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

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Chemical Property of [1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

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Technology Process of [1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

There total 7 articles about [1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 147247-29-8
methyl 2-(4-(bromomethyl)phenyl)-2-methylpropanoate

: 1247008-54-3
(4-piperidinylmethyl) 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 1247008-47-4
[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: With potassium carbonate; In acetone; for 24h; Reflux;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 152811-81-9
(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 1247008-47-4
[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / acetic acid; methanol / 48 h / 20 °C / 3750.38 Torr

2: potassium carbonate / acetone / 24 h / Reflux

With palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; acetic acid; acetone;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 938-94-3
(R,S)-2-(4'-methylphenyl) propionic acid

: 1247008-47-4
[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: sodium hydride / hexane / 24 h / 20 °C / Inert atmosphere

3: dibenzoyl peroxide; N-Bromosuccinimide / dichloromethane / 12 h / Reflux

4: potassium carbonate / acetone / 24 h / Reflux

With N-Bromosuccinimide; sodium hydride; sodium hydrogencarbonate; potassium carbonate; dibenzoyl peroxide; In hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.03.060