(9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone

Base Information

• Chemical Name: (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone
• CAS No.: 1263265-64-0
• Molecular Formula: C₂₃H₃₀ClN₃O₃S
• Molecular Weight: 464.029
• Mol file: 1263265-64-0.mol

Synonyms:(9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone

Chemical Property of (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone

There total 8 articles about (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-3-(2-hydroxyethyl)benzaldehyde (1179338-48-7) + (2-ethylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone (1263265-06-0) → (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone (1263265-64-0)

Guidance literature:

2-chloro-3-(2-hydroxyethyl)benzaldehyde; (2-ethylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone; With triethylamine; In dichloromethane; for 1.15h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 - 25 ℃; for 22.75h;

Reference yield:

2-chloro-3-(2-hydroxyethyl)benzaldehyde (1179338-48-7) + (2-ethylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate → (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone (1263265-64-0)

Guidance literature:

2-chloro-3-(2-hydroxyethyl)benzaldehyde; (2-ethylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate; With triethylamine; In tetrahydrofuran; for 0.5h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 2h;

Reference yield:

2-chloro-3-methylbenzoic acid (15068-35-6) → (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone (1263265-64-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / chlorobenzene / 4 h / 85 °C

2.1: N,N-dimethyl-formamide; water / 20 °C

2.2: 2 h / Inert atmosphere

3.1: water; sulfuric acid / 0.5 h / 165 °C / Reflux

4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.58 h / 20 °C / Reflux

5.1: manganese(IV) oxide / chloroform / 2 h / Reflux

6.1: triethylamine / tetrahydrofuran / 0.5 h

6.2: 2 h

With manganese(IV) oxide; N-Bromosuccinimide; dimethylsulfide borane complex; sulfuric acid; water; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; chlorobenzene;

upstream raw materials:

2-chloro-3-methylbenzoic acid

3-(bromomethyl)-2-chlorobenzoic acid

2-ethylthiazole-4-carboxylic acid

2-chloro-3-(2-hydroxyethyl)benzaldehyde

Downstream raw materials:

tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate

3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid

3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide