tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate

Base Information

• Chemical Name: tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate
• CAS No.: 1263265-65-1
• Molecular Formula: C₃₀H₄₂ClN₃O₅S
• Molecular Weight: 592.2
• Mol file: 1263265-65-1.mol

Synonyms:tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate

Chemical Property of tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate

There total 10 articles about tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone (1263265-64-0) → tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate (1263265-65-1)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In water; acetonitrile; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

2-chloro-3-methylbenzoic acid (15068-35-6) → tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate (1263265-65-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / chlorobenzene / 4 h / 85 °C

2.1: N,N-dimethyl-formamide; water / 20 °C

2.2: 2 h / Inert atmosphere

3.1: water; sulfuric acid / 0.5 h / 165 °C / Reflux

4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.58 h / 20 °C / Reflux

5.1: manganese(IV) oxide / chloroform / 2 h / Reflux

6.1: triethylamine / tetrahydrofuran / 0.5 h

6.2: 2 h

7.1: N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 1 h / 20 °C

With manganese(IV) oxide; N-Bromosuccinimide; dimethylsulfide borane complex; sulfuric acid; water; N-benzyl-trimethylammonium hydroxide; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; chlorobenzene; acetonitrile;

Reference yield:

tert-butyl 4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (1263265-05-9) → tert-butyl 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoate (1263265-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 22 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.5 h

2.2: 2 h

3.1: N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 1 h / 20 °C

With N-benzyl-trimethylammonium hydroxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;

upstream raw materials:

tert-Butyl acrylate

(9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone

2-chloro-3-methylbenzoic acid

3-(bromomethyl)-2-chlorobenzoic acid

Downstream raw materials:

3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid

3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide