tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane
CAS No.:182625-01-0
Molecular Formula:C₂₉H₅₀O₅SSi
Molecular Weight:538.865
Hs Code.:

tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

Synonyms:tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

There total 13 articles about tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 882-33-7
diphenyldisulfane

: 182823-32-1
[(1R,2S,3S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methoxymethoxymethyl-2-methyl-cyclohexyl]-methanol

: 182625-01-0
tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

Guidance literature:: With tributylphosphine; In pyridine; Ambient temperature;
DOI:10.1016/0040-4039(96)01585-7

Reference yield:

: 127642-52-8
ethyl (E)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methyl-2-propenoate

: 182625-01-0
tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 13 steps

1: 74 percent / LDA / tetrahydrofuran / -78 °C

2: NaBH₄ / methanol / 0 °C

3: pyridine / 0 °C

4: DBU / toluene / 100 °C

5: 1.) O₃, pyridine, Me₂S; 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, -78 deg C; 2.) 0 deg C

6: 99 percent / i-Pr₂NEt / 1,2-dichloro-ethane / 50 °C

7: 88 percent / LiAlH₄ / tetrahydrofuran / 0 °C

8: 75 percent / pyridine / 0 °C

9: imidazole / dimethylformamide / Ambient temperature

10: DIBAL-H / toluene / -78 °C

11: PDC, 4 Angstroem molecular sieves / CH₂Cl₂ / Ambient temperature

12: 1.) K₂CO₃; 2.) NaBH₄ / 1.) MeOH, RT; 2.) MeOH, 0 deg C

13: 96 percent / Bu₃P / pyridine / Ambient temperature

With pyridine; 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; dimethylsulfide; tributylphosphine; 4 A molecular sieve; diisobutylaluminium hydride; potassium carbonate; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4039(96)01585-7

Reference yield:

: 182624-80-2
[(1S,2S,3R,6S)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-3-methoxymethoxymethyl-1-methyl-cyclohexyl]-methanol

: 182625-01-0
tert-Butyl-[(1R,2S,3R,6R)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxymethyl-1-methyl-6-phenylsulfanylmethyl-cyclohexylmethoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / pyridine / 0 °C

2: imidazole / dimethylformamide / Ambient temperature

3: DIBAL-H / toluene / -78 °C

4: PDC, 4 Angstroem molecular sieves / CH₂Cl₂ / Ambient temperature

5: 1.) K₂CO₃; 2.) NaBH₄ / 1.) MeOH, RT; 2.) MeOH, 0 deg C

6: 96 percent / Bu₃P / pyridine / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; dipyridinium dichromate; tributylphosphine; 4 A molecular sieve; diisobutylaluminium hydride; potassium carbonate; In pyridine; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4039(96)01585-7