(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

Base Information

Chemical Name:(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione
CAS No.:1433993-06-6
Molecular Formula:C₁₉H₁₉F₃N₂O₃S₂
Molecular Weight:444.499
Hs Code.:

Synonyms:(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

Chemical Property:

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Technology Process of (R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

There total 8 articles about (R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1433993-05-5
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

: 1433993-06-6
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

Guidance literature:: With Lawessons reagent; In toluene; at 80 ℃; for 0.5h;

Reference yield:

: 1433992-98-3
(R)-ethyl 2-(N-(1-cyano-3-phenylpropan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

: 1433993-06-6
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

Guidance literature:: Multi-step reaction with 6 steps

1: platinum on activated charcoal; platinum(IV) oxide; hydrogen / methanol / 12 h / 2482.38 Torr

2: dmap; triethylamine / dichloromethane / 12 h / 20 °C

3: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

4: dichloromethane

5: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

6: Lawessons reagent / toluene / 0.5 h / 80 °C

With Lawessons reagent; dmap; platinum(IV) oxide; platinum on activated charcoal; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1433992-96-1
(R)-N-(1-cyano-3-phenylpropan-2-yl)-2-(trifluoromethoxy)benzenesulfonamide

: 1433993-06-6
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: platinum on activated charcoal; platinum(IV) oxide; hydrogen / methanol / 12 h / 2482.38 Torr

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C

4: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

5: dichloromethane

6: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

7: Lawessons reagent / toluene / 0.5 h / 80 °C

With Lawessons reagent; dmap; platinum(IV) oxide; platinum on activated charcoal; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;