(R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine

Base Information

Chemical Name:(R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine
CAS No.:1433991-83-3
Molecular Formula:C₂₁H₂₁F₃N₄O₃S
Molecular Weight:466.484
Hs Code.:

Synonyms:(R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine

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Chemical Property of (R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine

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Technology Process of (R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine

There total 9 articles about (R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1433993-06-6
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione

: 1068-57-1
acetic acid hydrazide

: 1433991-83-3
(R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: (R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepane-2-thione; acetic acid hydrazide; With mercury(II) diacetate; In tetrahydrofuran; at 0 ℃; for 2h;

With toluene-4-sulfonic acid; In water; toluene; at 75 ℃; for 12h;

Reference yield:

: 1433993-00-0
(R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

: 1433991-83-3
(R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: dichloromethane

4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

5.1: Lawessons reagent / toluene / 0.5 h / 80 °C

6.1: mercury(II) diacetate / tetrahydrofuran / 2 h / 0 °C

6.2: 12 h / 75 °C

With Lawessons reagent; dmap; mercury(II) diacetate; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1433993-02-2
(R)-2-(N-(4-((tert-butoxycarbonyl)amino)-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

: 1433991-83-3
(R)-7-benzyl-3-methyl-8-((2-(trifluoromethoxy)phenyl)sulfonyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

3.1: Lawessons reagent / toluene / 0.5 h / 80 °C

4.1: mercury(II) diacetate / tetrahydrofuran / 2 h / 0 °C

4.2: 12 h / 75 °C

With Lawessons reagent; mercury(II) diacetate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;