[1-(2-Hydroxy-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [1-(2-Hydroxy-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester
• CAS No.: 4864-80-6
• Molecular Formula: C₁₉H₂₂N₂O₄
• Molecular Weight: 342.395

Synonyms:[1-(2-Hydroxy-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

Chemical Property of [1-(2-Hydroxy-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

Chemical Property:

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Technology Process of [1-(2-Hydroxy-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

There total 13 articles about [1-(2-Hydroxy-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-Cbz-L-Phe (1161-13-3) + ethanolamine (141-43-5) → benzyl (S)-(1-((2-hydroxyethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (4864-80-6,22840-16-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 10h; Ambient temperature;

Reference yield: 83.0%

N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester (3397-32-8) + ethanolamine (141-43-5) → benzyl (S)-(1-((2-hydroxyethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (4864-80-6,22840-16-0)

Guidance literature:

In 1,4-dioxane; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2004.12.053

Reference yield: 70.0%

ethanolamine (141-43-5) + N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester (60379-01-3) → benzyl (S)-(1-((2-hydroxyethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (4864-80-6,22840-16-0)

Guidance literature:

With subtilisin BPN'; triethylamine; In water; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/ja964399w

upstream raw materials:

N-Cbz-L-Phe

ethanolamine

N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester

N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester

Downstream raw materials:

(S)-2-(2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)acetic acid

AQ₆₂₅₁₇₃

Boc-D-Arg(NO₂)-Phe-NH(CH₂)2OH

Boc-Tyr-D-Arg(NO₂)-Phe-NH(CH₂)2OH

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