4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde

Base Information

• Chemical Name: 4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde
• CAS No.: 1239964-34-1
• Molecular Formula: C₁₅H₂₂F₂O₃Si
• Molecular Weight: 316.42
• Mol file: 1239964-34-1.mol

Synonyms:4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde

Chemical Property of 4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde

There total 1 articles about 4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-difluoro-4-hydroxybenzaldehyde (532967-21-8) + 2-(tert-butyldimethylsilyloxy)ethyl bromide (86864-60-0) → 4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde (1239964-34-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 3h;

Reference yield: 90.0%

4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde (1239964-34-1) → (4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)methanol (1239964-35-2)

Guidance literature:

4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde; With sodium tetrahydroborate; In ethanol; for 1h;

With water; In ethanol;

Reference yield:

4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzaldehyde (1239964-34-1) → (E)-1-(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl)-2-cyanoguanidine (1240206-09-0)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium tetrahydroborate / ethanol / 1 h

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h

3: hydrogen fluoride / acetonitrile / 1 h

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 5 h / 2068.65 - 2327.23 Torr

7: isopropyl alcohol / 24 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; sodium azide; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

upstream raw materials:

2,6-difluoro-4-hydroxybenzaldehyde

2-(tert-butyldimethylsilyloxy)ethyl bromide

Downstream raw materials:

(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)methanol

2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethanol

2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate