Technology Process of 6-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydro-pyran-4-yl)-nicotinamide
There total 8 articles about 6-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydro-pyran-4-yl)-nicotinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / methanol / 6 h / Reflux
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere
2.2: 1 h / -75 - 20 °C
3.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 0 - 20 °C
5.1: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
With
methanol; sodium tetrahydroborate; n-butyllithium; lithium hydroxide monohydrate; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere
1.2: 1 h / -75 - 20 °C
2.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 0 - 20 °C
4.1: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
With
methanol; sodium tetrahydroborate; n-butyllithium; lithium hydroxide monohydrate; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; mineral oil;
