trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

Base Information

Chemical Name:trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate
CAS No.:1415573-11-3
Molecular Formula:C₂₂H₃₁NO₅
Molecular Weight:389.492
Hs Code.:

Synonyms:trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

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Chemical Property of trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

Chemical Property:

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Technology Process of trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

There total 9 articles about trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: C₁₂H₂₄O₃Si

: 1415573-11-3
trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

Guidance literature:: With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -60 - 0 ℃; for 0.5h;
DOI:10.1016/j.tet.2014.04.064

Reference yield:

: 99183-13-8
methyl 2-(4-hydroxycyclohexyl)acetate

: 1415573-11-3
trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

2.1: hydrogen; acetic acid / Rh/AI₂O₃ / 80 °C / 60006 Torr

3.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / -65 - 0 °C

4.1: ChiralPak AD / ethanol; carbon dioxide / Resolution of racemate

With chloro-trimethyl-silane; di-isopropyl azodicarboxylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; Rh/AI₂O₃; In tetrahydrofuran; ethanol; carbon dioxide;

Reference yield:

: 626-64-2,157061-69-3
pyridin-4-ol

: 1415573-11-3
trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

2.1: hydrogen; acetic acid / Rh/AI₂O₃ / 80 °C / 60006 Torr

3.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / -65 - 0 °C

4.1: ChiralPak AD / ethanol; carbon dioxide / Resolution of racemate

With chloro-trimethyl-silane; di-isopropyl azodicarboxylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; Rh/AI₂O₃; In tetrahydrofuran; ethanol; carbon dioxide;