N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide

Base Information

• Chemical Name: N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide
• CAS No.: 1356861-61-4
• Molecular Formula: C₁₂H₁₀N₄OS₂
• Molecular Weight: 290.37

Synonyms:N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide

Chemical Property of N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide

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Technology Process of N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide

There total 2 articles about N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-(5-mercapto-1,3,4-thiadiazol-2-yl)benzamide (33949-86-9) + acrylonitrile (107-13-1,25014-41-9) → N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide (1356861-61-4)

Guidance literature:

With triethylamine; In ethanol; for 6h; Reflux;

DOI:10.5012/bkcs.2011.32.12.4227

Reference yield:

benzoyl chloride (98-88-4) → N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide (1356861-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 8 h / 20 °C

2: triethylamine / ethanol / 6 h / Reflux

With triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.5012/bkcs.2011.32.12.4227

Reference yield: 80.0%

N-(4-(2-cyanoethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide (1356861-61-4) → N-(4-(3-hydrazino-3-iminopropyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide (1356861-63-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.5012/bkcs.2011.32.12.4227

upstream raw materials:

N-(5-mercapto-1,3,4-thiadiazol-2-yl)benzamide

acrylonitrile

benzoyl chloride

Downstream raw materials:

N-(4-(2-(2H-tetrazol-5-yl)ethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide

N-(4-(3-hydrazino-3-iminopropyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide

N-(4-(2-(5-mercapto-1,3,4-thiadiazol-2-yl)ethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)benzamide

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