rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide

Base Information

Chemical Name:rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide
CAS No.:1607432-17-6
Molecular Formula:C₂₂H₁₉FN₆OS
Molecular Weight:434.497
Hs Code.:

Synonyms:rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide

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Chemical Property of rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide

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Technology Process of rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide

There total 10 articles about rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607432-62-1
N-[[1-(5-fluoropyrimidin-2-yl)-4-(hydroxymethyl)-3-(3-pyridyl)pyrrolidin-3-yl]carbamothioyl]benzamide

: 1607432-17-6
rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide

Guidance literature:: With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 17694-68-7
3-(2-bromoacetyl)pyridine hydrobromide

: 1607432-17-6
rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 0 °C

3: triethylamine; titanium(IV) tetraethanolate / toluene / 5 h / 75 °C

4: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 110 °C

6: trifluoroacetic acid / 1 h / 60 °C

7: tetrahydrofuran / 2 h / 0 - 20 °C

8: zinc; acetic acid / 2 h / 20 °C / Sonication

9: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h / 0 °C

With titanium(IV) tetraethanolate; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 1607432-17-6
rac-N-[6-(5-fluoropyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo [3,4-d][1,3]thiazin-2-yl]benzamide

Guidance literature:: Multi-step reaction with 10 steps

1: hydrogen bromide; bromine / water; acetic acid / 0 - 75 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 0 °C

4: triethylamine; titanium(IV) tetraethanolate / toluene / 5 h / 75 °C

5: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 110 °C

7: trifluoroacetic acid / 1 h / 60 °C

8: tetrahydrofuran / 2 h / 0 - 20 °C

9: zinc; acetic acid / 2 h / 20 °C / Sonication

10: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h / 0 °C

With titanium(IV) tetraethanolate; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydrogen bromide; bromine; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid; toluene;