diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

Base Information

Chemical Name:diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate
CAS No.:1276109-96-6
Molecular Formula:C₃₀H₄₀N₅O₇PS
Molecular Weight:645.717
Hs Code.:

Synonyms:diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

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Chemical Property of diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

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Technology Process of diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

There total 6 articles about diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885618-05-3
C₂₁H₂₅N₅O₂S

: 5-(diethoxyphosphoryl)-4-oxopentanoic acid

: 1276109-96-6
diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

Guidance literature:: 5-(diethoxyphosphoryl)-4-oxopentanoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl acetamide; acetonitrile; at 20 ℃; for 0.5h;

C₂₁H₂₅N₅O₂S; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;
DOI:10.1021/jm3008745

Reference yield:

: 683-08-9
Diethyl methylphosphonate

: 1276109-96-6
diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide; acetonitrile / 0.5 h / 20 °C

2.2: 0.5 h / 20 °C

With n-butyllithium; 1,1'-carbonyldiimidazole; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/jm3008745

Reference yield:

: 885699-79-6
4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1276109-96-6
diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene; ethanol / 1 h / 120 °C / Inert atmosphere

2.1: hydrogenchloride; methanol / dichloromethane; 1,4-dioxane / 3 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide; acetonitrile / 0.5 h / 20 °C

3.2: 0.5 h / 20 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 1,1'-carbonyldiimidazole; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; acetonitrile; 1.1: |Suzuki Coupling;
DOI:10.1021/jm3008745