1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea

Base Information

Chemical Name:1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea
CAS No.:1200797-56-3
Molecular Formula:C₁₇H₂₆FN₅O₄S
Molecular Weight:415.489
Hs Code.:

Synonyms:1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea

There total 6 articles about 1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 4-methylpiperazine-1-sulfonyl chloride hydrochloride

: 1200798-08-8
1-(4-fluorophenyl)-3-(piperidin-4-yloxy)urea hydrochloride

: 1200797-56-3
1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea

Guidance literature:: With potassium carbonate; In 1,4-dioxane; water; at 20 ℃; for 18h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1200797-56-3
1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: hydrazine / ethanol / 0.5 h / 20 °C

3.1: pyrographite / tetrahydrofuran / 17.5 h / 0 - 20 °C

3.2: 17 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: potassium carbonate / 1,4-dioxane; water / 18 h / 20 °C

With hydrogenchloride; potassium carbonate; pyrographite; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1.1: Mitsunobu reaction;

Reference yield:

: 867034-25-1
tert-butyl 4-(aminooxy)piperidine-1-carboxylate

: 1200797-56-3
1-(4-fluorophenyl)-3-(1-(4-methylpiperazin-1-ylsulfonyl)piperidin-4-yloxy)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyrographite / tetrahydrofuran / 17.5 h / 0 - 20 °C

1.2: 17 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3.1: potassium carbonate / 1,4-dioxane; water / 18 h / 20 °C

With hydrogenchloride; potassium carbonate; pyrographite; In tetrahydrofuran; 1,4-dioxane; water;