(S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate
CAS No.:1378382-88-7
Molecular Formula:C₂₅H₂₃NO₆
Molecular Weight:433.461
Hs Code.:

Synonyms:(S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

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Chemical Property of (S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

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Technology Process of (S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

There total 1 articles about (S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66361-67-9
6-bromo-3,4-dihydro-2H-naphthalen-1-one

: 1378382-88-7
(S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.67 h / 0 - 20 °C

1.2: 0.5 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 60 °C

3.2: 1 h / 60 °C

3.3: 20 °C

With n-butyllithium; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexanes; dichloromethane; acetonitrile;

Reference yield: 74.0%

: 1378382-93-4
(S)-2-(2-(4-bromo-3-((methylsulfonyloxy)methyl)phenyl)-2-oxoethyl) 1-tert-butyl pyrrolidine-1,2-dicarboxylate

: 1378382-88-7
(S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

: 1378382-95-6
(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1378382-88-7
(S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

: 1378382-96-7
(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

With sodium acetate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide;