(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

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Chemical Name:(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate
CAS No.:1378382-96-7
Molecular Formula:C₄₄H₄₄N₂O₁₁
Molecular Weight:776.84
Hs Code.:

(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

Synonyms:(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

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Chemical Property of (S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

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Technology Process of (S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

There total 10 articles about (S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1378382-95-6
(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

: 1378382-96-7
(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

Guidance literature:: With sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 110 ℃; for 6h; Inert atmosphere;

Reference yield:

: 25252-00-0
2-bromo-5-iodobenzoic acid

: 1378382-96-7
(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diazomethyl-trimethyl-silane / dichloromethane; hexanes; methanol / 12 h / 20 °C

1.2: 122 h / 20 °C

1.3: 2 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

2.2: 2 h / -20 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 60 °C

3.2: 1 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

With TurboGrignard; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; diazomethyl-trimethyl-silane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; hexanes; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1378382-90-1
(2-bromo-5-iodobenzyloxy)(tert-butyl)dimethylsilane

: 1378382-96-7
(S)-1-benzyl 2-(2-(8-(2-((S)-1-(tert-butoxycarbonyl)-pyrroolidine-2-carbonyloxy)acetyl)-6H-dibenzo-[c,h]chromen-2-yl)-2-oxoethyl) pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: TurboGrignard / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

1.2: 2 h / -20 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 60 °C

2.2: 1 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

With TurboGrignard; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;