(3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester

Base Information

Chemical Name:(3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester
CAS No.:937816-19-8
Molecular Formula:C₂₆H₂₂F₃NO₄
Molecular Weight:469.46
Hs Code.:

Synonyms:(3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester

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Chemical Property of (3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester

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Technology Process of (3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester

There total 7 articles about (3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937400-31-2
[(3S,5R)-5-(3,4,5-trifluorophenyl)morpholine-3-yl]methanol

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 937816-19-8
(3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 20 ℃; for 15.1667h;

Reference yield:

: 937400-28-7
(5S)-5-[(benzyloxy)methyl]morpholin-3-one

: 937816-19-8
(3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / acetonitrile / 3 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 2 h / -40 - -35 °C

3.1: hydrogenchloride / ethyl acetate / 12 h / 20 °C

3.2: 22 h

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 15.17 h / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; dmap; In tetrahydrofuran; diethyl ether; water; ethyl acetate; acetonitrile;

Reference yield:

: 138526-69-9
3,4,5-trifluoro-1-bromobenzene

: 937816-19-8
(3S,5R)-3-hydroxymethyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / iodine / diethyl ether / 1 - 1.5 h / 20 °C / Heating / reflux

2.1: tetrahydrofuran; diethyl ether / 2 h / -40 - -35 °C

3.1: hydrogenchloride / ethyl acetate / 12 h / 20 °C

3.2: 22 h

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 15.17 h / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; magnesium; iodine; In tetrahydrofuran; diethyl ether; water; ethyl acetate;