1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one

Base Information

• Chemical Name: 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one
• CAS No.: 169250-67-3
• Molecular Formula: C₂₈H₂₇ClN₂O₂
• Molecular Weight: 458.988

Synonyms:1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one

Chemical Property of 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one

Chemical Property:

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Technology Process of 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one

There total 1 articles about 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Tropic acid (529-64-6,28845-94-5) + descarboethoxyloratadine (100643-71-8) → 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one (169250-67-3)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 4 ℃; for 0.5h;

DOI:10.1016/S0968-0896(96)00206-4

Reference yield: 91.0%

acetyl chloride (75-36-5) + 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one (169250-67-3) → Acetic acid 3-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-oxo-2-phenyl-propyl ester

Guidance literature:

for 4h; Ambient temperature;

DOI:10.1016/S0968-0896(96)00206-4

Reference yield: 73.0%

methanesulfonyl chloride (124-63-0) + 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-hydroxy-2-phenyl-propan-1-one (169250-67-3) → 8-CHLORO-11-[1-(2-METHYLSULFONYLOXY-1-PHENYLETHYL-CARBONYL)-4-PIPERIDYLIDENE]-6,11-DIHYDRO-5H-BENZO[5,6]-CYCLOHEPTA[1,2-b]-PYRIDINE (169250-92-4)

Guidance literature:

With pyridine; for 12h; Ambient temperature;

DOI:10.1016/S0968-0896(96)00206-4

upstream raw materials:

Tropic acid

descarboethoxyloratadine

Downstream raw materials:

8-CHLORO-11-[1-(2-METHYLSULFONYLOXY-1-PHENYLETHYL-CARBONYL)-4-PIPERIDYLIDENE]-6,11-DIHYDRO-5H-BENZO[5,6]-CYCLOHEPTA[1,2-b]-PYRIDINE

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