5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one

Base Information

• Chemical Name: 5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one
• CAS No.: 1051925-12-2
• Molecular Formula: C₂₃H₂₃N₃O₃S₂
• Molecular Weight: 453.586

Synonyms:5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one

Chemical Property of 5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one

There total 1 articles about 5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-(2-methylallyl)-2-thioxo-5-(1-tosyl-1H-indol-3-yl)imidazolidin-4-one (1051925-11-1) + methyl iodide (74-88-4) → 5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one (1051925-12-2)

Guidance literature:

5-(2-methylallyl)-2-thioxo-5-(1-tosyl-1H-indol-3-yl)imidazolidin-4-one; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; Inert atmosphere;

methyl iodide; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol801375k

Reference yield: 91.0%

5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one (1051925-12-2) + dimethyl amine (124-40-3) → 2-(dimethylamino)-5-(2-methylallyl)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one (1051925-13-3)

Guidance literature:

In tetrahydrofuran; at 75 - 90 ℃; for 14h; Inert atmosphere;

DOI:10.1021/ol801375k

Reference yield: 72.0%

5-(2-methylallyl)-2-(methylthio)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one (1051925-12-2) → 2-amino-5-(2-methylallyl)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one (1146981-73-8)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; water; at 90 ℃; Inert atmosphere;

DOI:10.1021/jo900264p

upstream raw materials:

5-(2-methylallyl)-2-thioxo-5-(1-tosyl-1H-indol-3-yl)imidazolidin-4-one

methyl iodide

Downstream raw materials:

2-(dimethylamino)-5-(2-methylallyl)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one

2-amino-5-(2-methylallyl)-5-(1-tosyl-1H-indol-3-yl)-1H-imidazol-4(5H)-one

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