2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

Base Information

Chemical Name:2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid
CAS No.:114359-59-0
Molecular Formula:C₁₆H₂₂N₂O₄
Molecular Weight:306.362
Hs Code.:

Synonyms:2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

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Chemical Property of 2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

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Technology Process of 2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

There total 3 articles about 2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 114359-58-9
Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate

: 114359-59-0
2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water;

Reference yield:

: 78775-63-0
diethyl α-(1-methyl-1-phenylethyl)malonate

: 114359-59-0
2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KOH, 2.) HCl / 1.) EtOH, 90 deg C , 1 h; 50 deg C, 20 h, 2.) H₂O

2: 1.) triethylamine, diphenyl phosphorazidate / 1.) toluene, 100 deg C, 2.5 h, 2.) room temperature

3: 82 percent / NaOH / dioxane; H₂O / 16 h / 35 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; water;
DOI:10.1021/jm00120a006

Reference yield:

: 97441-39-9
ethyl hydrogen (α,α-dimethylbenzyl)malonate

: 114359-59-0
2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, diphenyl phosphorazidate / 1.) toluene, 100 deg C, 2.5 h, 2.) room temperature

2: 82 percent / NaOH / dioxane; H₂O / 16 h / 35 °C

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; water;
DOI:10.1021/jm00120a006