Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate

Base Information

• Chemical Name: Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate
• CAS No.: 114359-58-9
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.415

Synonyms:Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate

Chemical Property of Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate

Chemical Property:

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Technology Process of Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate

There total 4 articles about Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl hydrogen (α,α-dimethylbenzyl)malonate (97441-39-9) + diphenylphosphoranyl azide (4129-17-3) → Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate (114359-58-9)

Guidance literature:

With triethylamine; In toluene;

Reference yield:

diethyl α-(1-methyl-1-phenylethyl)malonate (78775-63-0) → Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate (114359-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KOH, 2.) HCl / 1.) EtOH, 90 deg C , 1 h; 50 deg C, 20 h, 2.) H₂O

2: 1.) triethylamine, diphenyl phosphorazidate / 1.) toluene, 100 deg C, 2.5 h, 2.) room temperature

With hydrogenchloride; potassium hydroxide; diphenyl phosphoryl azide; triethylamine;

DOI:10.1021/jm00120a006

Reference yield:

morpholine (110-91-8,99108-56-2) + ethyl hydrogen (α,α-dimethylbenzyl)malonate (97441-39-9) → Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate (114359-58-9)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; Yield given. Multistep reaction; 1.) toluene, 100 deg C, 2.5 h, 2.) room temperature;

DOI:10.1021/jm00120a006

upstream raw materials:

morpholine

ethyl hydrogen (α,α-dimethylbenzyl)malonate

diethyl α-(1-methyl-1-phenylethyl)malonate

diphenylphosphoranyl azide

Downstream raw materials:

Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-L-β,β-dimethylphenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid

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