Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

Base Information

Chemical Name:Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide
CAS No.:116183-35-8
Molecular Formula:C₃₆H₅₆N₆O₆
Molecular Weight:668.877
Hs Code.:

Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

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Chemical Property of Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

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Technology Process of Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

There total 4 articles about Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78775-63-0
diethyl α-(1-methyl-1-phenylethyl)malonate

: 116183-35-8
Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOH, 2.) HCl / 1.) EtOH, 90 deg C , 1 h; 50 deg C, 20 h, 2.) H₂O

2: 1.) triethylamine, diphenyl phosphorazidate / 1.) toluene, 100 deg C, 2.5 h, 2.) room temperature

3: 82 percent / NaOH / dioxane; H₂O / 16 h / 35 °C

4: DCC / dimethylformamide / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006

Reference yield:

: 97441-39-9
ethyl hydrogen (α,α-dimethylbenzyl)malonate

: 116183-35-8
Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, diphenyl phosphorazidate / 1.) toluene, 100 deg C, 2.5 h, 2.) room temperature

2: 82 percent / NaOH / dioxane; H₂O / 16 h / 35 °C

3: DCC / dimethylformamide / Ambient temperature

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006

Reference yield:

: 114359-58-9
Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate

: 116183-35-8
Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / NaOH / dioxane; H₂O / 16 h / 35 °C

2: DCC / dimethylformamide / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006