5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Base Information

Chemical Name:5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole
CAS No.:197151-40-9
Molecular Formula:C₃₅H₄₆N₂O₇SSi
Molecular Weight:666.911
Hs Code.:

5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Synonyms:5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

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Chemical Property of 5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

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Technology Process of 5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

There total 3 articles about 5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 123-11-5
4-methoxy-benzaldehyde

: 197151-42-1
4-Bromo-5-[(tert-butyl-dimethyl-silanyloxy)-(3,4-dimethoxy-2-methoxymethoxy-phenyl)-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

: 197151-40-9
5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Guidance literature:: 4-Bromo-5-[(tert-butyl-dimethyl-silanyloxy)-(3,4-dimethoxy-2-methoxymethoxy-phenyl)-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

4-methoxy-benzaldehyde; In tetrahydrofuran; pentane; at -78 ℃; for 3h; Further stages.;
DOI:10.1039/b200845a

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 197151-40-9
5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / dimethylformamide / 12 h / 60 °C

2: 64 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / -30 °C

3: 1.) t-BuLi / 1.) pentane, ether, 23 deg C, 2 min, 2.) pentane, ether, -78 deg C, 1 h

With 1H-imidazole; N-Bromosuccinimide; tert.-butyl lithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1393

Reference yield:

: 197151-41-0
5-[(tert-Butyl-dimethyl-silanyloxy)-(3,4-dimethoxy-2-methoxymethoxy-phenyl)-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

: 197151-40-9
5-[1-(tert-butyldimethylsiloxy)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)methyl]-4-[1-hydroxy-1-(4-methoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / -30 °C

2: 1.) t-BuLi / 1.) pentane, ether, 23 deg C, 2 min, 2.) pentane, ether, -78 deg C, 1 h

With N-Bromosuccinimide; tert.-butyl lithium; In tetrahydrofuran;
DOI:10.1248/cpb.45.1393