methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate

Base Information

Chemical Name:methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate
CAS No.:1378949-47-3
Molecular Formula:C₂₇H₂₆N₄O₉
Molecular Weight:550.525
Hs Code.:

Synonyms:methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate

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Chemical Property of methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate

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Technology Process of methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate

There total 4 articles about methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1378949-42-8
methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

: 103-80-0
phenylacetyl chloride

: 1378949-47-3
methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 196194-97-5
N-(4-methoxy-2-methyl-5-nitrophenyl)acetamide

: 1378949-47-3
methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium permanganate; magnesium sulfate / water / 1.5 h / 80 °C / Inert atmosphere

2.1: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere

3.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

3.2: 18 h / Inert atmosphere; Reflux

4.1: dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; potassium permanganate; thionyl chloride; magnesium sulfate; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 102-50-1
2-methyl-4-methoxyaniline

: 1378949-47-3
methyl 2-acetamido-5-methoxy-4-(5-methoxy-4-nitro-2-(2-phenylacetamido)benzamido)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C / Inert atmosphere

3.1: potassium permanganate; magnesium sulfate / water / 1.5 h / 80 °C / Inert atmosphere

4.1: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere

5.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

5.2: 18 h / Inert atmosphere; Reflux

6.1: dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; potassium permanganate; thionyl chloride; magnesium sulfate; trifluoroacetic acid; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.11.010