methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

Base Information

Chemical Name:methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride
CAS No.:1378949-42-8
Molecular Formula:C₁₉H₂₀N₄O₈*ClH
Molecular Weight:468.851
Hs Code.:

Synonyms:methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

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Chemical Property of methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

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Technology Process of methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

There total 3 articles about methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1378949-37-1
methyl 2-acetamido-4-amino-5-methoxybenzoate

: 1378949-39-3
2-amino-5-methoxy-4-nitrobenzoic acid hydrochloride

: 1378949-42-8
methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

Guidance literature:: 2-amino-5-methoxy-4-nitrobenzoic acid hydrochloride; With thionyl chloride; for 1h; Inert atmosphere; Reflux;

methyl 2-acetamido-4-amino-5-methoxybenzoate; In tetrahydrofuran; for 18h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 196194-98-6
2-acetamido-5-methoxy-4-nitrobenzoic acid

: 1378949-42-8
methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere

2.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

2.2: 18 h / Inert atmosphere; Reflux

With hydrogenchloride; thionyl chloride; In water;
DOI:10.1016/j.tet.2011.11.010

Reference yield:

: 102-50-1
2-methyl-4-methoxyaniline

: 1378949-42-8
methyl 2-acetamido-4-(2-amino-5-methoxy-4-nitrobenzamido)-5-methoxybenzoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C / Inert atmosphere

3.1: potassium permanganate; magnesium sulfate / water / 1.5 h / 80 °C / Inert atmosphere

4.1: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere

5.1: thionyl chloride / 1 h / Inert atmosphere; Reflux

5.2: 18 h / Inert atmosphere; Reflux

With pyridine; hydrogenchloride; potassium permanganate; thionyl chloride; magnesium sulfate; trifluoroacetic acid; sodium nitrite; In water;
DOI:10.1016/j.tet.2011.11.010