N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol

Base Information

Chemical Name:N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol
CAS No.:1549714-67-1
Molecular Formula:C₂₂H₂₆N₂O₃S₂
Molecular Weight:430.592
Hs Code.:

Synonyms:N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol

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Chemical Property of N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol

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Technology Process of N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol

There total 4 articles about N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 1380676-39-0
4-methyl-N-(2-propyn-1-yl)-N-[3-(phenylthio)-2-propyn-1-yl]benzenesulfonamide

: 1549714-67-1
N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; bis(hexafluoroacetylacetonato)nickel(II) monohydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 20 ℃; for 72h; Reagent/catalyst; Time;
DOI:10.1016/j.tet.2013.12.049

Reference yield:

: 89005-19-6
3-(phenylsulfanyl)propargyl alcohol

: 1549714-67-1
N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol

Guidance literature:: Multi-step reaction with 2 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere

2: bis(hexafluoroacetylacetonato)nickel(II) monohydrate; bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 72 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; bis(hexafluoroacetylacetonato)nickel(II) monohydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dimethyl sulfoxide; 1: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.12.049

Reference yield:

: 931-59-9
benzenesulfenyl chloride

: 1549714-67-1
N-[3-(phenylsulfanylmethyl)-1-(4-methylphenylsulfonyl)pyrrol-4-ylmethyl]-N-methylaminoethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: toluene-4-sulfonic acid / isopropyl alcohol; diethyl ether / 12 h / 20 °C / Inert atmosphere

3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere

4.1: bis(hexafluoroacetylacetonato)nickel(II) monohydrate; bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 72 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; bis(hexafluoroacetylacetonato)nickel(II) monohydrate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; isopropyl alcohol; 3.1: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.12.049