ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate

Base Information

Chemical Name:ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate
CAS No.:1426943-69-2
Molecular Formula:C₂₀H₃₀N₂O₄
Molecular Weight:362.469
Hs Code.:

Synonyms:ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate

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Chemical Property of ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate

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Technology Process of ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate

There total 3 articles about ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1426943-67-0
ethyl 5-[methyl(tert-butoxycarbonyl)amino]-3-oxopentanoate

: 106-49-0,12221-03-3
p-toluidine

: 1426943-69-2
ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate

Guidance literature:: With acetic acid; at 20 ℃; for 18h;
DOI:10.1039/c3ob00039g

Reference yield:

: 124072-61-3
N-t-butoxycarbonyl-N-methyl-β-alanine

: 1426943-69-2
ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 2 h / 20 °C / Inert atmosphere

1.2: 40 °C / Inert atmosphere

2.1: acetic acid / 18 h / 20 °C

With acetic acid; 1,1'-carbonyldiimidazole; In acetonitrile;
DOI:10.1039/c3ob00039g

Reference yield:

: 119740-95-3
methyl 3-(N-tert-butoxycarbonyl-N-methyl)-aminopropionate

: 1426943-69-2
ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 20 °C

2.1: 1,1'-carbonyldiimidazole / acetonitrile / 2 h / 20 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

3.1: acetic acid / 18 h / 20 °C

With acetic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In ethanol; water; acetonitrile;
DOI:10.1039/c3ob00039g