4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether

Base Information

Chemical Name:4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether
CAS No.:119795-30-1
Molecular Formula:C₂₂H₂₆O₇
Molecular Weight:402.444
Hs Code.:

Synonyms:4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether

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Chemical Property of 4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether

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Technology Process of 4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether

There total 6 articles about 4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40492-52-2
2,3-dihydrobenzofuran-5-ol

: 119795-30-1
4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether

Guidance literature:: Multi-step reaction with 7 steps

1: 76.9 percent / Br₂ / CH₂Cl₂ / Ambient temperature

2: 1) NaH / 1) DMF, T < 40 deg C, 2) r.t., 2 h

3: 1) n-BuLi / 1) THF, hexane, -70 deg C, 2 h, 2) a) T < -60 deg C, 1 h, b) to 0 deg C, 40 min

4: 1.42 g / p-nitroperoxybenzoic acid / CH₂Cl₂ / 24 h / Heating

5: 57 percent / KOH / methanol; H₂O / 1 h / Ambient temperature

6: 1) NaH / 1) DMF, 2) DMF, 2 h

7: 1) NaH / 1) DMF, 2) DMF, 60 deg C

With potassium hydroxide; n-butyllithium; p-nitroperoxybenzoic acid; bromine; sodium hydride; In methanol; dichloromethane; water;
DOI:10.1021/jm00125a014

Reference yield:

: 40492-53-3
2,3-dihydro-6-bromo-5-hydroxybenzofuran

: 119795-30-1
4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether

Guidance literature:: Multi-step reaction with 6 steps

1: 1) NaH / 1) DMF, T < 40 deg C, 2) r.t., 2 h

2: 1) n-BuLi / 1) THF, hexane, -70 deg C, 2 h, 2) a) T < -60 deg C, 1 h, b) to 0 deg C, 40 min

3: 1.42 g / p-nitroperoxybenzoic acid / CH₂Cl₂ / 24 h / Heating

4: 57 percent / KOH / methanol; H₂O / 1 h / Ambient temperature

5: 1) NaH / 1) DMF, 2) DMF, 2 h

6: 1) NaH / 1) DMF, 2) DMF, 60 deg C

With potassium hydroxide; n-butyllithium; p-nitroperoxybenzoic acid; sodium hydride; In methanol; dichloromethane; water;
DOI:10.1021/jm00125a014

Reference yield:

: 119795-13-0
2,3-Dihydro-5-hydroxybenzofuran-6-carboxaldehyde methoxymethyl ether

: 119795-30-1
4-<3-<(2,3-Dihydro-5-hydroxy-6-benzofuranyl)oxy>propoxy>benzeneacetic acid methyl ester methoxymethyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 1.42 g / p-nitroperoxybenzoic acid / CH₂Cl₂ / 24 h / Heating

2: 57 percent / KOH / methanol; H₂O / 1 h / Ambient temperature

3: 1) NaH / 1) DMF, 2) DMF, 2 h

4: 1) NaH / 1) DMF, 2) DMF, 60 deg C

With potassium hydroxide; p-nitroperoxybenzoic acid; sodium hydride; In methanol; dichloromethane; water;
DOI:10.1021/jm00125a014