5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

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Chemical Name:5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine
CAS No.:1341200-59-6
Molecular Formula:C₂₆H₃₀ClFN₆O₂S
Molecular Weight:545.081
Hs Code.:

Synonyms:5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

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Chemical Property of 5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

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Technology Process of 5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

There total 5 articles about 5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1341200-92-7
2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

: 70261-82-4
4-[(4-methyl-1-piperazinyl)methyl]aniline

: 1341200-59-6
5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tert-butyl alcohol; for 12h; Reflux;
DOI:10.1021/ml200198x

Reference yield: 96.0%

: 1341200-59-6
5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

Guidance literature:

Reference yield:

: 1341200-89-2
2,5-dichloro-4-(4-fluorophenyl)pyrimidine

: 1341200-59-6
5-chloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: chlorosulfonic acid / 4 h

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tert-butyl alcohol / 12 h / Reflux

With chlorosulfonic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; tert-butyl alcohol; 3: Buchwald-Hartwig amination;
DOI:10.1021/ml200198x