2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

Base Information

Chemical Name:2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine
CAS No.:1341200-92-7
Molecular Formula:C₁₄H₁₂Cl₂FN₃O₂S
Molecular Weight:0
Hs Code.:
Mol file:1341200-92-7.mol

Synonyms:2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

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Chemical Property of 2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

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Technology Process of 2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

There total 3 articles about 2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123-75-1
pyrrolidine

: 1341200-90-5
2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

: 1341200-92-7
2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ml200198x

Reference yield:

: 1341200-89-2
2,5-dichloro-4-(4-fluorophenyl)pyrimidine

: 1341200-92-7
2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: chlorosulfonic acid / 4 h

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ml200198x

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1341200-92-7
2,5-dichloro-4-(4-fluoro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; sodium carbonate; triphenylphosphine / tetrahydrofuran; water / 12 h / Reflux

2: chlorosulfonic acid / 4 h

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With chlorosulfonic acid; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; water; 1: Suzuki coupling;
DOI:10.1021/ml200198x