2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

Base Information

Chemical Name:2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride
CAS No.:1341200-90-5
Molecular Formula:C₁₀H₄Cl₃FN₂O₂S
Molecular Weight:0
Hs Code.:
Mol file:1341200-90-5.mol

Synonyms:2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

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Chemical Property of 2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

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Technology Process of 2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

There total 2 articles about 2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1341200-89-2
2,5-dichloro-4-(4-fluorophenyl)pyrimidine

: 1341200-90-5
2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

Guidance literature:: With chlorosulfonic acid; for 4h;
DOI:10.1021/ml200198x

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1341200-90-5
2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; sodium carbonate; triphenylphosphine / tetrahydrofuran; water / 12 h / Reflux

2: chlorosulfonic acid / 4 h

With chlorosulfonic acid; palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; 1: Suzuki coupling;
DOI:10.1021/ml200198x