trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1)

Base Information

• Chemical Name: trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1)
• CAS No.: 1357001-80-9
• Molecular Formula: C₆H₈O₇*C₃₃H₃₂FN₃OS
• Molecular Weight: 729.826

Synonyms:trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1)

Chemical Property of trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1)

Chemical Property:

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Technology Process of trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1)

There total 4 articles about trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

AMD-3trans (1357001-79-6) + citric acid (77-92-9,906507-37-7) → trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1) (1357001-80-9)

Guidance literature:

In diethyl ether; ethanol; at 20 - 80 ℃; for 72h;

Reference yield:

[8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride (1002916-54-2) → trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1) (1357001-80-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: methanol / 16 h / Inert atmosphere

2.2: 2 h / 20 °C

2.3: 1 h / cooling with ice

3.1: tetrahydrofuran / 3.25 h / 20 °C / Inert atmosphere

3.2: 2.5 h / cooling with ice

4.1: diethyl ether; ethanol / 72 h / 20 - 80 °C

With hydrogenchloride; water; In tetrahydrofuran; methanol; diethyl ether; ethanol;

Reference yield:

4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one (863514-54-9) → trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1) (1357001-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 16 h / Inert atmosphere

1.2: 2 h / 20 °C

1.3: 1 h / cooling with ice

2.1: tetrahydrofuran / 3.25 h / 20 °C / Inert atmosphere

2.2: 2.5 h / cooling with ice

3.1: diethyl ether; ethanol / 72 h / 20 - 80 °C

In tetrahydrofuran; methanol; diethyl ether; ethanol;

upstream raw materials:

benzothiophene-2-carboxylic acid chloride

AMN-2trans

AMD-3trans

citric acid

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