{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid

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Chemical Name:{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid
CAS No.:1086424-35-2
Molecular Formula:C₂₁H₂₀ClFN₂O₄
Molecular Weight:418.852
Hs Code.:

Synonyms:{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid

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Chemical Property of {2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid

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Technology Process of {2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid

There total 8 articles about {2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1086424-98-7
{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

: 1086424-35-2
{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid

Guidance literature:: With sulfuric acid; water; In acetic acid; at 90 ℃; for 18h;

Reference yield:

: 1086424-96-5
8'-chloro-5'-[2-(chloromethyl)-6-fluorophenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

: 1086424-35-2
{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 18 h / 20 °C

2: sulfuric acid; water / acetic acid / 18 h / 90 °C

With sulfuric acid; water; In acetic acid; dimethyl sulfoxide;

Reference yield:

: 1086424-45-4
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

: 1086424-35-2
{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; water / acetic acid / 18 h / 60 - 110 °C

2: sulfuric acid / 72 h / Heating / reflux

3: methanol; lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 80 °C / Heating / reflux

4: pyridine; thionyl chloride / dichloromethane / 2 h / 0 °C / Heating / reflux

5: dimethyl sulfoxide / 18 h / 20 °C

6: sulfuric acid; water / acetic acid / 18 h / 90 °C

With pyridine; methanol; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; water; In tetrahydrofuran; dichloromethane; acetic acid; dimethyl sulfoxide;