{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

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Chemical Name:{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile
CAS No.:1086424-98-7
Molecular Formula:C₂₁H₁₉ClFN₃O₂
Molecular Weight:399.852
Hs Code.:

Synonyms:{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

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Chemical Property of {2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

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Technology Process of {2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

There total 7 articles about {2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1086424-96-5
8'-chloro-5'-[2-(chloromethyl)-6-fluorophenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

: 143-33-9,25596-52-5
sodium cyanide

: 1086424-98-7
{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 18h;

Reference yield:

: 1086424-45-4
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

: 1086424-98-7
{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; water / acetic acid / 18 h / 60 - 110 °C

2: sulfuric acid / 72 h / Heating / reflux

3: methanol; lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 80 °C / Heating / reflux

4: pyridine; thionyl chloride / dichloromethane / 2 h / 0 °C / Heating / reflux

5: dimethyl sulfoxide / 18 h / 20 °C

With pyridine; methanol; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; water; In tetrahydrofuran; dichloromethane; acetic acid; dimethyl sulfoxide;

Reference yield:

: 1086424-19-2
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzoic acid

: 1086424-98-7
{2-[(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy]-3-fluorophenyl}acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 72 h / Heating / reflux

2: methanol; lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 80 °C / Heating / reflux

3: pyridine; thionyl chloride / dichloromethane / 2 h / 0 °C / Heating / reflux

4: dimethyl sulfoxide / 18 h / 20 °C

With pyridine; methanol; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;