8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

Base Information

Chemical Name:8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one
CAS No.:1086424-94-3
Molecular Formula:C₂₀H₂₀ClFN₂O₃
Molecular Weight:390.842
Hs Code.:

Synonyms:8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

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Chemical Property of 8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

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Technology Process of 8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

There total 5 articles about 8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.3%

: 1086424-39-6
methyl 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzoate

: 1086424-94-3
8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

Guidance literature:: methyl 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzoate; With methanol; lithium aluminium tetrahydride; In tetrahydrofuran; at 80 ℃; for 18h; Heating / reflux;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 1086424-45-4
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

: 1086424-94-3
8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; water / acetic acid / 18 h / 60 - 110 °C

2: sulfuric acid / 72 h / Heating / reflux

3: methanol; lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 80 °C / Heating / reflux

With methanol; lithium aluminium tetrahydride; sulfuric acid; water; In tetrahydrofuran; acetic acid;

Reference yield:

: 21524-39-0
2,3-difluorobenzonitrile

: 1086424-94-3
8'-chloro-5'-[2-fluoro-6-(hydroxymethyl)phenoxy]-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C

2: sulfuric acid; water / acetic acid / 18 h / 60 - 110 °C

3: sulfuric acid / 72 h / Heating / reflux

4: methanol; lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 80 °C / Heating / reflux

With methanol; lithium aluminium tetrahydride; sulfuric acid; water; caesium carbonate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;