4-ACETAMIDOBENZYL ALCOHOL

Base Information

• Chemical Name: 4-ACETAMIDOBENZYL ALCOHOL
• CAS No.: 16375-88-5
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• Mol file: 16375-88-5.mol

Synonyms:p-Acetotoluidide,a-hydroxy- (7CI,8CI);4-Acetamidobenzyl alcohol; 4-Hydroxymethylacetanilide;N-[4-(Hydroxymethyl)phenyl]acetamide; p-(Acetylamino)benzyl alcohol

Chemical Property of 4-ACETAMIDOBENZYL ALCOHOL

Chemical Property:

• Appearance/Colour: Colorless transparent liquid
• Vapor Pressure: 4.78E-07mmHg at 25°C
• Melting Point: 120-122°C
• Refractive Index: 1.605
• Boiling Point: 120-122
• PKA: 14.37±0.10(Predicted)
• Flash Point: 194.5 °C
• PSA: 49.33000
• Density: 1.211 g/cm³
• LogP: 1.21030
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-AcetamidobenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ACETAMIDOBENZYL ALCOHOL

There total 26 articles about 4-ACETAMIDOBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-aminobenzenemethanol (623-04-1) + acetic anhydride (108-24-7) → N-(4-hydroxymethylphenyl)acetamide (16375-88-5)

Guidance literature:

With Co₃O₄ nanoparticles; at 20 ℃; for 0.2h; chemoselective reaction; Green chemistry;

DOI:10.1007/s11164-016-2631-7

Reference yield: 95.0%

4-nitrobenzaldehdye (555-16-8) + ethyl acetate (141-78-6) → N-(4-hydroxymethylphenyl)acetamide (16375-88-5)

Guidance literature:

4-nitrobenzaldehdye; With sodium tetrahydroborate; In ethyl acetate;

ethyl acetate; With bis(dimethylglyoximato)copper(II); for 2.83333h; Reflux;

DOI:10.1002/jccs.201800325

Reference yield: 94.0%

4-aminobenzenemethanol (623-04-1) + potassium thioacetate (10387-40-3) → N-(4-hydroxymethylphenyl)acetamide (16375-88-5)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; In acetonitrile; at 20 ℃; Irradiation;

DOI:10.1021/acscatal.5b02943

upstream raw materials:

para-acetamidobenzaldehyde

N-(pivaloyloxy)-p-acetotoluidide

4-aminobenzenemethanol

acetic anhydride

Downstream raw materials:

4'-fluoroacetanilide

4-acetamidobenzyl chloride

para-acetamidobenzaldehyde

2-oxopropionic acid 4-acetylaminobenzyl ester