N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1439877-05-0
Molecular Formula:C₂₆H₂₀F₃N₅O₄
Molecular Weight:523.471
Hs Code.:

Synonyms:N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 6 articles about N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439878-82-6
1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxylic acid [4-(2-acetylaminopyridin-4-yloxy)-2,5-difluorophenyl]amide

: 74-89-5
methylamine

: 1439877-05-0
N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: In methanol; at 80 ℃; for 3h;

Reference yield:

: 1025721-07-6
1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde

: 1439877-05-0
N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tetrahydrofuran; tert-butyl alcohol / 1 h / 0 - 25 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4: methanol / 3 h / 80 °C

With sodium chlorite; sodium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; water; toluene; tert-butyl alcohol;

Reference yield:

: 158669-26-2
4-iodo-2-methoxynicotinaldehyde

: 1439877-05-0
N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 2.25 h / 15 - 25 °C

2: copper diacetate; n-tetradecanoic acid; 2,6-dimethylpyridine / toluene / 96 h

3: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tetrahydrofuran; tert-butyl alcohol / 1 h / 0 - 25 °C

4: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / Reflux

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

6: methanol / 3 h / 80 °C

With 2,6-dimethylpyridine; sodium chlorite; sodium dihydrogenphosphate; chloro-trimethyl-silane; thionyl chloride; 2-methyl-but-2-ene; copper diacetate; n-tetradecanoic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; methanol; water; toluene; acetonitrile; tert-butyl alcohol;