5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Base Information

Chemical Name:5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile
CAS No.:851635-07-9
Molecular Formula:C₂₂H₂₇N₅O₂
Molecular Weight:393.489
Hs Code.:

Synonyms:5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

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Chemical Property of 5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

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Technology Process of 5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

There total 9 articles about 5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044661-23-5
N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide

: 851635-07-9
5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Guidance literature:: In methanol; Heating / reflux;

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 851635-07-9
5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C

1.2: 4 h / 20 °C

2.1: triethyloxonium hexaflourophosphate / dichloromethane / 48 h / 20 °C

2.2: 24 h / 60 °C

3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 18 h / 100 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 18 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

9.1: triethylamine / dichloromethane / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

11.1: methanol / Heating / reflux

With 4-methyl-morpholine; sodium tris(acetoxy)borohydride; sodium hydride; triethyloxonium hexaflourophosphate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 625840-40-6
[1-(3-benzyl-5-methyl-6-hydroxy-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid t-butyl ester

: 851635-07-9
5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 18 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

5.1: triethylamine / dichloromethane / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: methanol / Heating / reflux

With sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;