2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid

Base Information

Chemical Name:2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid
CAS No.:1198785-30-6
Molecular Formula:C₁₉H₂₅F₃O₃Si
Molecular Weight:386.486
Hs Code.:

Synonyms:2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid

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Chemical Property of 2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid

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Technology Process of 2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid

There total 9 articles about 2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 1198785-29-3
2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzoic acid

: 1198785-30-6
2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid

Guidance literature:: chloro-trimethyl-silane; 2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzoic acid; With 1H-imidazole; In N,N-dimethyl-formamide; for 2h;

With hydrogenchloride; In diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1198785-60-2
4-(2-[1,3]dioxan-2-ylphenyl)-1,1,1-trifluoro-4-methylpentan-2-one

: 1198785-30-6
2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminium; mercury dichloride / tetrahydrofuran / 1 h / 50 °C

1.2: 2 h / -78 - 20 °C

2.1: hydrogenchloride / tetrahydrofuran; water / 16 h / 40 °C

3.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 16 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; aluminium; mercury dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ml500387y

Reference yield:

: 1198785-28-2
5,5-dimethyl-3-prop-2-ynyl-3-trifluoromethyl-1,3,4,5-tetrahydrobenzo[c]oxepin-1-ol

: 1198785-30-6
2-(1,1-dimethyl-3-trifluoromethyl-3-trimethylsilanyloxy-hex-5-ynyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 16 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ml500387y