3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

Base Information

Chemical Name:3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide
CAS No.:1369377-42-3
Molecular Formula:C₂₂H₁₅ClN₄O₄S
Molecular Weight:466.904
Hs Code.:

Synonyms:3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

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Chemical Property of 3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

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Technology Process of 3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

There total 5 articles about 3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1369377-33-2
3-(4-chlorophenyl)-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

: 74-88-4
methyl iodide

: 1369377-42-3
3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

Guidance literature:: 3-(4-chlorophenyl)-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;
DOI:10.1021/jm201446h

Reference yield:

: 1369377-26-3
(4-chlorophenyl)(4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)methanone

: 1369377-42-3
3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / ethanol / 48 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

With sulfuric acid; sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm201446h

Reference yield:

: 41335-62-0
2-[2-(4-chlorophenyl)-2-oxoethyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide

: 1369377-42-3
3-(4-chlorophenyl)-4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; sodium ethanolate / 3 h / 60 °C

2.1: sulfuric acid / ethanol / 48 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

With ethanol; sulfuric acid; sodium ethanolate; sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm201446h